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About us

The immune system plays a fundamental role in health and disease and efficiently protects vertebrate hosts from infections and cancer. However, failures in its regulation can cause autoimmunity, allergy, immunodeficiencies and malignancies. To understand the mechanisms underlying these processes and how they can be manipulated for the benefit of humans and animals, immunologists use a wide range of experimental methods. The efficient handling of thereby generated data, so that they meet the scientific demands for reproducibility and reusability, is currently one of the key challenges for immunological research. NFDI4Immuno aims to initiate and shape the necessary transformation process together with its community. 15 partner institutions (10 co-applicants and 5 participants) ensure the broad anchoring in the scientific community as a whole as well as in the respective thematic domains.

Goals

  • Harmonize data representations, metadata standards, ontologies and programmatic interfaces within NFDI
  • Facilitate NFDI-wide queries and cross-references
  • Provide consistent metadata annotation to existing and new data sets and make them available through our repositories
  • Enable and support users to utilize the resources provided by NFDI4Immuno
  • Promote the adoption of FAIR practices by the immunological community, in support of the cultural change towards Open Science
  • Build and operate a network of federated repositories for immunological data
  • Develop tools and services that will facilitate standardized and reproducible data analyses

Task Areas

NFDI4Immuno TA eng

Use Cases

One of the planned activities of NFDI4Immuno is to establish federated repositories for immune receptor repertoire data. These data will allow conclusions about how strongly and how specifically subsets of immune cells have been activated by, e.g., a virus. As the genetic blueprint of immunoglobulins and T cell receptors, they also provide the basis for therapeutic antibodies and adaptive T cell therapies. NFDI4Immuno therefore operates repositories for these data, actively participates in the further development of the software stack used by the community for this purpose and will curate and publish its own and already public third-party data.

folgt

Dr. Christian Busse

Speaker of the consortium

(Co-)applicant institutions and (co-)speakers:
  • Charité – Universitätsmedizin Berlin, Prof. Dr. Michael Hummel
  • German Rheumatism Research Center (DRFZ), Prof. Dr. Hyun-Dong Chang
  • DKMS gGmbH, Prof. Dr. Johannes Schetelig
  • University of Tübingen (EKUT), Prof. Dr. Sven Nahnsen
  • Friedrich-Loeffler-Institut (FLI), Prof. Dr. Anca Dorhoi
  • Helmholtz Centre for Infection Research (HZI), Prof. Dr. Michael Meyer-Hermann
  • Ruhr-Universität Bochum (RUB), Prof. Dr. Nina Babel
  • University of Münster, Prof. Dr. Nicholas Schwab
  • Universitätsmedizin Essen (UME), Prof. Dr. Ralf Küppers
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German Cancer Research Center (DKFZ)

Applicant institution

Participating Institutions
  • German Federal Institute for Risk Assessment (BfR), Dr. Katherina Siewert
  • Charité – Universitätsmedizin Berlin, PD Dr. Cornelia Eckert
  • University of Bonn, Prof. Dr. Felix Meissner
  • Technical University of Munich (TUM), Prof. Dr. Dietmar Zehn
  • University of Greifswald (UGW), Prof. Dr. Barbara M. Bröker
  • Universitätsklinikum Frankfurt (KGU), Dr. Katharina Imkeller
folgt

Dr. Christian Busse

Speaker of the consortium

DKFZ Logo

German Cancer Research Center (DKFZ)

Applicant institution

(Co-)applicant institutions and (co-)speakers:
  • Charité – Universitätsmedizin Berlin, Prof. Dr. Michael Hummel
  • German Rheumatism Research Center (DRFZ), Prof. Dr. Hyun-Dong Chang
  • DKMS gGmbH, Prof. Dr. Johannes Schetelig
  • University of Tübingen (EKUT), Prof. Dr. Sven Nahnsen
  • Friedrich-Loeffler-Institut (FLI), Prof. Dr. Anca Dorhoi
  • Helmholtz Centre for Infection Research (HZI), Prof. Dr. Michael Meyer-Hermann
  • Ruhr-Universität Bochum (RUB), Prof. Dr. Nina Babel
  • University of Münster, Prof. Dr. Nicholas Schwab
  • Universitätsmedizin Essen (UME), Prof. Dr. Ralf Küppers
Participating Institutions
  • German Federal Institute for Risk Assessment (BfR), Dr. Katherina Siewert
  • Charité – Universitätsmedizin Berlin, PD Dr. Cornelia Eckert
  • University of Bonn, Prof. Dr. Felix Meissner
  • Technical University of Munich (TUM), Prof. Dr. Dietmar Zehn
  • University of Greifswald (UGW), Prof. Dr. Barbara M. Bröker
  • Universitätsklinikum Frankfurt (KGU), Dr. Katharina Imkeller